A SECRET WEAPON FOR GR

Just one nucleotide polymorphism that replaces A with G with the nucleoside 3669 (A3669G) located in the 3’ end of exon 9b has been described in a ecu population (461). This polymorphism does not alter the amino acid sequence but improves the steadiness of GRb mRNA and boosts GRb protein expression, leading to larger inhibition of GRa-induced tra